| Titre : |
Evaluation des effets thérapeutiques de l'huile essentielle de néroliCitrus aurantium en aromathérapie |
| Type de document : |
texte imprimé |
| Auteurs : |
Sonia Ait Mokhtar, Auteur ; Raouane Bahloul, Auteur ; Guici EL kouacheur khadidja, Auteur |
| Editeur : |
Tipaza [Algérie] : Centre universitaire Morsli Abdellah - Tipaza- |
| Année de publication : |
2024/2025 |
| Importance : |
p.88 |
| Présentation : |
couv. en noir et blanc ., ill., fig.,tabl. |
| Format : |
30 cm |
| Accompagnement : |
CD |
| Note générale : |
Bibliographie: p70-80.
Annexes: p81-86. |
| Langues : |
Français (fre) |
| Catégories : |
Biochimie
|
| Mots-clés : |
Citrus aurantium essential oil analgesic activity neuroprotection anti-inflammatory activity aluminum chloride DPPH. |
| Index. décimale : |
572.05 |
| Résumé : |
In a context marked by the rising prevalence of neurodegenerative and inflammatory diseases, as well as the limitations of conventional therapies, this study investigates the therapeutic potential of neroli essential oil (EO) extracted from Citrus aurantium flowers harvested in Tipaza (Algeria). A combined in vitro and in vivo approach was adopted to assess its antioxidant, anti-inflammatory, analgesic, and neuroprotective properties.
The antioxidant activity evaluated by the DPPH assay revealed low to moderate efficacy. The anti-inflammatory effect, assessed using a murine model of xylene-induced ear edema, showed a maximum inhibition of 60.3% with the EO diluted to 10%, suggesting optimal effectiveness at moderate concentration. The acetic acid-induced writhing test demonstrated a strong, dose-dependent analgesic activity, with up to 87.5% inhibition at 50 mg/kg.
Furthermore, a model of neurotoxicity induced by aluminum chloride was used to evaluate the neuroprotective effect of the EO at three doses (50, 100, and 150 mg/kg). The 100 mg/kg dose proved to be the most effective, leading to significant improvements in memory performance (Morris water maze test), reduced inflammatory markers (CRP, LDH), and better histological preservation of brain tissue.
These findings support the traditional uses of neroli and suggest that the 100 mg/kg dose may represent a promising natural option for preventing neurodegenerative diseases such as Alzheimer’s and managing chronic inflammation. Further studies are needed to elucidate the underlying molecular mechanisms and to explore the potential of this essential oil in topical or nutraceutical formulations.
|
Evaluation des effets thérapeutiques de l'huile essentielle de néroliCitrus aurantium en aromathérapie [texte imprimé] / Sonia Ait Mokhtar, Auteur ; Raouane Bahloul, Auteur ; Guici EL kouacheur khadidja, Auteur . - Tipaza [Algérie] : Centre universitaire Morsli Abdellah - Tipaza-, 2024/2025 . - p.88 : couv. en noir et blanc ., ill., fig.,tabl. ; 30 cm + CD. Bibliographie: p70-80.
Annexes: p81-86. Langues : Français ( fre)
| Catégories : |
Biochimie
|
| Mots-clés : |
Citrus aurantium essential oil analgesic activity neuroprotection anti-inflammatory activity aluminum chloride DPPH. |
| Index. décimale : |
572.05 |
| Résumé : |
In a context marked by the rising prevalence of neurodegenerative and inflammatory diseases, as well as the limitations of conventional therapies, this study investigates the therapeutic potential of neroli essential oil (EO) extracted from Citrus aurantium flowers harvested in Tipaza (Algeria). A combined in vitro and in vivo approach was adopted to assess its antioxidant, anti-inflammatory, analgesic, and neuroprotective properties.
The antioxidant activity evaluated by the DPPH assay revealed low to moderate efficacy. The anti-inflammatory effect, assessed using a murine model of xylene-induced ear edema, showed a maximum inhibition of 60.3% with the EO diluted to 10%, suggesting optimal effectiveness at moderate concentration. The acetic acid-induced writhing test demonstrated a strong, dose-dependent analgesic activity, with up to 87.5% inhibition at 50 mg/kg.
Furthermore, a model of neurotoxicity induced by aluminum chloride was used to evaluate the neuroprotective effect of the EO at three doses (50, 100, and 150 mg/kg). The 100 mg/kg dose proved to be the most effective, leading to significant improvements in memory performance (Morris water maze test), reduced inflammatory markers (CRP, LDH), and better histological preservation of brain tissue.
These findings support the traditional uses of neroli and suggest that the 100 mg/kg dose may represent a promising natural option for preventing neurodegenerative diseases such as Alzheimer’s and managing chronic inflammation. Further studies are needed to elucidate the underlying molecular mechanisms and to explore the potential of this essential oil in topical or nutraceutical formulations.
|
|  |
Affiner la recherche Interroger des sources externesEvaluation des effets thérapeutiques de l'huile essentielle de néroliCitrus aurantium en aromathérapie / Sonia Ait Mokhtar
