| Titre : |
Study of Biochemical Mechanisms of pharmacological Activities In Traditional Formulation Based on Carduncellus caeruleus |
| Type de document : |
texte imprimé |
| Auteurs : |
Ines Belaissi, Auteur ; Imen Miloudi, Auteur ; Guici EL kouacheur khadidja, Auteur |
| Editeur : |
Tipaza [Algérie] : Centre universitaire Morsli Abdellah - Tipaza- |
| Année de publication : |
2024/2025 |
| Importance : |
p.70 |
| Présentation : |
couv. en noir et blanc ., ill., fig. |
| Format : |
30 cm |
| Accompagnement : |
CD |
| Note générale : |
Bibliographie: p50-58.
Annexes: p59-68. |
| Langues : |
Français (fre) |
| Catégories : |
Biochimie
|
| Mots-clés : |
Carduncellus caeruleus L. nano emulsion anti-inflammatory effect DDPH healing cream. |
| Index. décimale : |
572.11 |
| Résumé : |
The objective of this study was to evaluate the pharmacological effects (anti- inflammatory, wound healing, and antioxidant) of both a nano formulation and a traditional cream based on Carduncellus caeruleus and to better understand its mechanisms of action in order to scientifically validate its use in traditional medicine.
An ethnobotanical survey was conducted using an online questionnaire distributed via Google Forms. A total of 113 participants of different ages, genders, and educational levels were surveyed. Most responses were positive regarding this plant, which is highly valued for treating burns.
Pharmacologically, the topical administration of the C. caeruleus nano formulation significantly reduced xylene-induced inflammatory edema with a reduction rate of 91.71%, followed by the traditional formulation, which showed a reduction rate of 89.89%. However, the positive control (diclofenac®) exhibited the lowest reduction rate at 10.70%. This activity was further confirmed at the cellular level through histopathological analysis. The antioxidant activity was evaluated in vitro using the DPPH method. Results showed a concentration-dependent increase in antioxidant effect, indicating dose -dependent activity. The extract exhibited moderate radical scavenging capacity with an IC₅₀ value of 153.22 ± 0.22 µg/mL, which was notably lower than that of the reference antioxidants.
The aqueous extract of C. caeruleus, incorporated into a dermal cream nano emulsion and traditional formulation, also demonstrated remarkable efficacy in the healing of circular wounds, with wound contraction rates of 96.71% and 95.76%, respectively, surpassing those observed with Madécassol® (72.09%) and the negative control (96.36%). These findings were corroborated by histopathological sections and biochemical analyses, particularly CBC and CRP measurements.
The nano formulation and traditional cream of C. caeruleus confirm their anti-inflammatory, antioxidant, and wound-healing efficacy, thereby supporting its traditional use.
|
Study of Biochemical Mechanisms of pharmacological Activities In Traditional Formulation Based on Carduncellus caeruleus [texte imprimé] / Ines Belaissi, Auteur ; Imen Miloudi, Auteur ; Guici EL kouacheur khadidja, Auteur . - Tipaza [Algérie] : Centre universitaire Morsli Abdellah - Tipaza-, 2024/2025 . - p.70 : couv. en noir et blanc ., ill., fig. ; 30 cm + CD. Bibliographie: p50-58.
Annexes: p59-68. Langues : Français ( fre)
| Catégories : |
Biochimie
|
| Mots-clés : |
Carduncellus caeruleus L. nano emulsion anti-inflammatory effect DDPH healing cream. |
| Index. décimale : |
572.11 |
| Résumé : |
The objective of this study was to evaluate the pharmacological effects (anti- inflammatory, wound healing, and antioxidant) of both a nano formulation and a traditional cream based on Carduncellus caeruleus and to better understand its mechanisms of action in order to scientifically validate its use in traditional medicine.
An ethnobotanical survey was conducted using an online questionnaire distributed via Google Forms. A total of 113 participants of different ages, genders, and educational levels were surveyed. Most responses were positive regarding this plant, which is highly valued for treating burns.
Pharmacologically, the topical administration of the C. caeruleus nano formulation significantly reduced xylene-induced inflammatory edema with a reduction rate of 91.71%, followed by the traditional formulation, which showed a reduction rate of 89.89%. However, the positive control (diclofenac®) exhibited the lowest reduction rate at 10.70%. This activity was further confirmed at the cellular level through histopathological analysis. The antioxidant activity was evaluated in vitro using the DPPH method. Results showed a concentration-dependent increase in antioxidant effect, indicating dose -dependent activity. The extract exhibited moderate radical scavenging capacity with an IC₅₀ value of 153.22 ± 0.22 µg/mL, which was notably lower than that of the reference antioxidants.
The aqueous extract of C. caeruleus, incorporated into a dermal cream nano emulsion and traditional formulation, also demonstrated remarkable efficacy in the healing of circular wounds, with wound contraction rates of 96.71% and 95.76%, respectively, surpassing those observed with Madécassol® (72.09%) and the negative control (96.36%). These findings were corroborated by histopathological sections and biochemical analyses, particularly CBC and CRP measurements.
The nano formulation and traditional cream of C. caeruleus confirm their anti-inflammatory, antioxidant, and wound-healing efficacy, thereby supporting its traditional use.
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572 
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