| Titre : |
L'intéret dosage de la troponine hypersensible dans le diagnostic du syndrome coronarien aigue et son interaction avec les dysfonctionnements hépatiques |
| Type de document : |
texte imprimé |
| Auteurs : |
Bouchra Elkaldi, Auteur ; Kheira Henni, Auteur ; Sabah Gheddouchi, Auteur |
| Editeur : |
Tipaza [Algérie] : Centre universitaire Morsli Abdellah - Tipaza- |
| Année de publication : |
2024/2025 |
| Importance : |
p.86 |
| Présentation : |
couv. en noir et blanc ., ill., fig.,tabl. |
| Format : |
30 cm |
| Accompagnement : |
CD |
| Note générale : |
Bibliographie: p70-78.
Annexes: p81-86. |
| Langues : |
Français (fre) |
| Catégories : |
Biochimie
|
| Mots-clés : |
ACS troponin TNNT2 gene LXR polymorphism (SNPs). |
| Index. décimale : |
572.06 |
| Résumé : |
Acute coronary syndrome (ACS) is a cardiac emergency requiring rapid and reliable diagnosis. Hypersensitive troponin is the gold standard biomarker of myocardial damage, but its interpretation can be influenced by liver function and lipid profile. The objective of this study was to evaluate the value of hypersensitive troponin testing in ACS and associated liver and lipid alterations.
The study involved a total of 87 patients admitted for ACS to the Tipaza EPH (Educational Hospital for the Elderly) with a mean age of 64 ± 9.98 years and a male/female sex ratio of 1.9. The study focused on troponin testing, liver function tests (AST, ALT, alkaline phosphatase, and gamma-GT enzymes), and lipid parameters (cholesterol and triglycerides). In parallel, an in silico approach was carried out on the TNNT2 gene by exploiting bioinformatics databases (NCBI, Ensembl, UniProt, KEGG) in order to identify polymorphisms (SNPs), and to explore their potential interaction with the hepatic nuclear receptor LXR, involved in lipid metabolism.
Our results revealed that 56 subjects had elevated troponin levels. In addition, liver function test abnormalities observed included elevations in AST (35%), ALT (18%), ALP (47%), and Gamma-GT (39%). Regarding lipids, hypercholesterolemia was found in 27% of patients, associated with hypertriglyceridemia in 23%. In parallel, in silico analysis identified genetic variations within the TNNT2 gene and simulated molecular interactions between troponin and the LXR (Liver X Receptor).
|
L'intéret dosage de la troponine hypersensible dans le diagnostic du syndrome coronarien aigue et son interaction avec les dysfonctionnements hépatiques [texte imprimé] / Bouchra Elkaldi, Auteur ; Kheira Henni, Auteur ; Sabah Gheddouchi, Auteur . - Tipaza [Algérie] : Centre universitaire Morsli Abdellah - Tipaza-, 2024/2025 . - p.86 : couv. en noir et blanc ., ill., fig.,tabl. ; 30 cm + CD. Bibliographie: p70-78.
Annexes: p81-86. Langues : Français ( fre)
| Catégories : |
Biochimie
|
| Mots-clés : |
ACS troponin TNNT2 gene LXR polymorphism (SNPs). |
| Index. décimale : |
572.06 |
| Résumé : |
Acute coronary syndrome (ACS) is a cardiac emergency requiring rapid and reliable diagnosis. Hypersensitive troponin is the gold standard biomarker of myocardial damage, but its interpretation can be influenced by liver function and lipid profile. The objective of this study was to evaluate the value of hypersensitive troponin testing in ACS and associated liver and lipid alterations.
The study involved a total of 87 patients admitted for ACS to the Tipaza EPH (Educational Hospital for the Elderly) with a mean age of 64 ± 9.98 years and a male/female sex ratio of 1.9. The study focused on troponin testing, liver function tests (AST, ALT, alkaline phosphatase, and gamma-GT enzymes), and lipid parameters (cholesterol and triglycerides). In parallel, an in silico approach was carried out on the TNNT2 gene by exploiting bioinformatics databases (NCBI, Ensembl, UniProt, KEGG) in order to identify polymorphisms (SNPs), and to explore their potential interaction with the hepatic nuclear receptor LXR, involved in lipid metabolism.
Our results revealed that 56 subjects had elevated troponin levels. In addition, liver function test abnormalities observed included elevations in AST (35%), ALT (18%), ALP (47%), and Gamma-GT (39%). Regarding lipids, hypercholesterolemia was found in 27% of patients, associated with hypertriglyceridemia in 23%. In parallel, in silico analysis identified genetic variations within the TNNT2 gene and simulated molecular interactions between troponin and the LXR (Liver X Receptor).
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572 
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