| Titre : |
Caractérisation phytochimique et étude des activités: antioxydante anti-inflammatoire et anti-diabétique de différents extraits de Salvia Barrélieri(Lamiaceae) |
| Type de document : |
texte imprimé |
| Auteurs : |
Sahel Dounia, Auteur ; Salim Aimeur, Auteur ; Della Nassima Mostefa, Auteur |
| Editeur : |
Tipaza [Algérie] : Centre universitaire Morsli Abdellah - Tipaza- |
| Année de publication : |
2024/2025 |
| Importance : |
p.71 |
| Présentation : |
couv. en noir et blanc ., ill., fig. |
| Format : |
30 cm |
| Accompagnement : |
CD |
| Note générale : |
Bibliographie: p65-71. |
| Langues : |
Français (fre) |
| Catégories : |
Biochimie
|
| Mots-clés : |
Salvia barrelieri polyphenols flavonoids RP-HPLC antioxidant activity antidiabetic activity anti-inflammatory activity ultrasound-assisted extraction α-amylase bioactive compounds. |
| Index. décimale : |
572.04 |
| Résumé : |
In the context of promoting natural resources to combat chronic diseases, Salvia barrelieri (Lamiaceae), a traditionally used but scientifically underexplored Algerian medicinal plant, was investigated for its pharmacological potential. The objective was to characterize its phytochemical profile and assess the antioxidant, antidiabetic, and anti-inflammatory activities of its methanolic and ethanolic extracts, obtained through ultrasound-assisted extraction (UAE). Quantification assays revealed higher contents of total phenolic compounds (43.88 mg GAE/g) and total flavonoids (37.5 mg QE/g) in the methanolic extract. This extract also showed superior antioxidant activity (DPPH and ABTS assays), with IC₅₀ values lower than that of BHT. Antidiabetic activity, measured via α-amylase inhibition, showed an IC₅₀ of 9.57 µg/mL for the methanolic extract compared to 94.18 µg/mL for acarbose. Anti-inflammatory activity, assessed by inhibition of albumin denaturation, exceeded 85%, comparable to diclofenac. RP-HPLC analysis identified four major compounds in the hydro-methanolic extract: salicylic acid, apigenin, hesperetin, and varingenin, all known for their pharmacological properties. These findings highlight the significant impact of solvent choice on extract composition and biological efficacy, positioning the methanolic extract as the most promising. Further studies, especially in vivo, are required to isolate active constituents and confirm their therapeutic relevance. |
Caractérisation phytochimique et étude des activités: antioxydante anti-inflammatoire et anti-diabétique de différents extraits de Salvia Barrélieri(Lamiaceae) [texte imprimé] / Sahel Dounia, Auteur ; Salim Aimeur, Auteur ; Della Nassima Mostefa, Auteur . - Tipaza [Algérie] : Centre universitaire Morsli Abdellah - Tipaza-, 2024/2025 . - p.71 : couv. en noir et blanc ., ill., fig. ; 30 cm + CD. Bibliographie: p65-71. Langues : Français ( fre)
| Catégories : |
Biochimie
|
| Mots-clés : |
Salvia barrelieri polyphenols flavonoids RP-HPLC antioxidant activity antidiabetic activity anti-inflammatory activity ultrasound-assisted extraction α-amylase bioactive compounds. |
| Index. décimale : |
572.04 |
| Résumé : |
In the context of promoting natural resources to combat chronic diseases, Salvia barrelieri (Lamiaceae), a traditionally used but scientifically underexplored Algerian medicinal plant, was investigated for its pharmacological potential. The objective was to characterize its phytochemical profile and assess the antioxidant, antidiabetic, and anti-inflammatory activities of its methanolic and ethanolic extracts, obtained through ultrasound-assisted extraction (UAE). Quantification assays revealed higher contents of total phenolic compounds (43.88 mg GAE/g) and total flavonoids (37.5 mg QE/g) in the methanolic extract. This extract also showed superior antioxidant activity (DPPH and ABTS assays), with IC₅₀ values lower than that of BHT. Antidiabetic activity, measured via α-amylase inhibition, showed an IC₅₀ of 9.57 µg/mL for the methanolic extract compared to 94.18 µg/mL for acarbose. Anti-inflammatory activity, assessed by inhibition of albumin denaturation, exceeded 85%, comparable to diclofenac. RP-HPLC analysis identified four major compounds in the hydro-methanolic extract: salicylic acid, apigenin, hesperetin, and varingenin, all known for their pharmacological properties. These findings highlight the significant impact of solvent choice on extract composition and biological efficacy, positioning the methanolic extract as the most promising. Further studies, especially in vivo, are required to isolate active constituents and confirm their therapeutic relevance. |
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