| Titre : |
La relation entre la dysbiose intestinale et les infections urinaires chez les patients atteints le diabète de type 2 |
| Type de document : |
texte imprimé |
| Auteurs : |
Feriel Dhikra Mohamed Cherif, Auteur ; Rihab Saidi, Auteur ; imene Ammam, Auteur |
| Editeur : |
Tipaza [Algérie] : Centre universitaire Morsli Abdellah - Tipaza- |
| Année de publication : |
2024/2025 |
| Importance : |
p.80 |
| Présentation : |
couv. en noir et blanc ., ill., fig. |
| Format : |
30 cm |
| Accompagnement : |
CD |
| Note générale : |
Bibliographie: p59-65.
Annexes: p66-80. |
| Langues : |
Français (fre) |
| Catégories : |
Microbiologie
|
| Mots-clés : |
Type 2 Diabetes Gut Dysbiosis Urinary Tract Infection Microbiota Antibiogram Bacterial Resistance. |
| Index. décimale : |
579.46 |
| Résumé : |
Type 2 diabetes is a chronic metabolic disease frequently associated with an increased risk of infections, particularly urinary tract infections (UTIs), due to persistent hyperglycemia and weakened immunity. This study aims to investigate the relationship between gut dysbiosis and urinary tract infections in patients with type 2 diabetes.
The study involved 19 patients with type 2 diabetes, from whom urine samples (n = 19) and stool samples (n = 15) were collected and analyzed, focusing on subjects with urinary tract infections, some of whom were hospitalized. Results showed that 63.1% of urine samples were positive, with Escherichia coli identified as the predominant pathogen (31.6% of cases).
A relationship between gut microbiota and UTIs was established through two main findings: a concordance in antibiotic resistance profiles between urinary and fecal strains in several patients, and an increased abundance of the bacterial family to which the urinary pathogen belonged (mainly Enterobacteriaceae) in the stool samples.
These findings suggest a possible translocation of pathogenic intestinal strains to the urinary tract. Furthermore, 16.6% of the isolated strains were extended-spectrum beta-lactamase (ESBL) producers, complicating their therapeutic management.
Data analysis identified several risk factors associated with the occurrence and recurrence of UTIs: intestinal dysbiosis, poor diet, inappropriate antibiotic therapy (without antibiogram), long-standing diabetes, chronic hyperglycemia, advanced age, chronic diseases, prolonged hospitalization, and catheter use.
These results support the hypothesis of a link between the gut microbiota state and urinary tract infections in diabetic patients and emphasize the importance of targeted preventive strategies in a context of increasing bacterial resistance.
|
La relation entre la dysbiose intestinale et les infections urinaires chez les patients atteints le diabète de type 2 [texte imprimé] / Feriel Dhikra Mohamed Cherif, Auteur ; Rihab Saidi, Auteur ; imene Ammam, Auteur . - Tipaza [Algérie] : Centre universitaire Morsli Abdellah - Tipaza-, 2024/2025 . - p.80 : couv. en noir et blanc ., ill., fig. ; 30 cm + CD. Bibliographie: p59-65.
Annexes: p66-80. Langues : Français ( fre)
| Catégories : |
Microbiologie
|
| Mots-clés : |
Type 2 Diabetes Gut Dysbiosis Urinary Tract Infection Microbiota Antibiogram Bacterial Resistance. |
| Index. décimale : |
579.46 |
| Résumé : |
Type 2 diabetes is a chronic metabolic disease frequently associated with an increased risk of infections, particularly urinary tract infections (UTIs), due to persistent hyperglycemia and weakened immunity. This study aims to investigate the relationship between gut dysbiosis and urinary tract infections in patients with type 2 diabetes.
The study involved 19 patients with type 2 diabetes, from whom urine samples (n = 19) and stool samples (n = 15) were collected and analyzed, focusing on subjects with urinary tract infections, some of whom were hospitalized. Results showed that 63.1% of urine samples were positive, with Escherichia coli identified as the predominant pathogen (31.6% of cases).
A relationship between gut microbiota and UTIs was established through two main findings: a concordance in antibiotic resistance profiles between urinary and fecal strains in several patients, and an increased abundance of the bacterial family to which the urinary pathogen belonged (mainly Enterobacteriaceae) in the stool samples.
These findings suggest a possible translocation of pathogenic intestinal strains to the urinary tract. Furthermore, 16.6% of the isolated strains were extended-spectrum beta-lactamase (ESBL) producers, complicating their therapeutic management.
Data analysis identified several risk factors associated with the occurrence and recurrence of UTIs: intestinal dysbiosis, poor diet, inappropriate antibiotic therapy (without antibiogram), long-standing diabetes, chronic hyperglycemia, advanced age, chronic diseases, prolonged hospitalization, and catheter use.
These results support the hypothesis of a link between the gut microbiota state and urinary tract infections in diabetic patients and emphasize the importance of targeted preventive strategies in a context of increasing bacterial resistance.
|
|  |
579.01 
Affiner la recherche Interroger des sources externesLa relation entre la dysbiose intestinale et les infections urinaires chez les patients atteints le diabète de type 2
