| Titre : |
Effets antimicrobien et biologiques de psidium guajava de la région de Tipaza |
| Type de document : |
texte imprimé |
| Auteurs : |
Rahma Hachelaf, Auteur ; Mouna Merrouche, Auteur |
| Editeur : |
Tipaza [Algérie] : Centre universitaire Morsli Abdellah - Tipaza- |
| Année de publication : |
2024/2025 |
| Importance : |
p.67 |
| Présentation : |
couv. en noir et blanc ., ill., fig. |
| Format : |
30 cm |
| Accompagnement : |
CD |
| Note générale : |
Bibliographie: p57-63.
Annexes: p64-67. |
| Langues : |
Français (fre) |
| Catégories : |
Microbiologie
|
| Mots-clés : |
Psidium guajava leaves extract Soxhlet polyphenols high-performance liquid chromatography (HPLC) antioxidant antibacterial antifungal anti-biofilm anti-inflammatory flavonoids Candida albicans. |
| Index. décimale : |
579.44 |
| Résumé : |
This research focused on evaluating the phytochemical, antioxidant, antimicrobial, anti-biofilm, and anti-inflammatory properties of Psidium guajava L. (guava) leaves collected from Bou-Ismaïl (Tipaza, Algeria). Bioactive compounds were extracted using a Soxhlet apparatus with a methanol (80%)/water (20%) mixture, yielding 6.35%. HPLC analysis identified thirteen phenolic and flavonoid compounds, including gallic acid, myricetin, and apigenin. Antioxidant activity was assessed through total polyphenol content (232.5904 µg GAE/mg extract), DPPH radical scavenging (IC50 = 8 mg/L), and FRAP method (258.153 µmol Fe²⁺/g dry extract). The antimicrobial activity was tested against thirteen bacterial strains (three reference, five pathogenic, and five multidrug-resistant) and one fungal strain (Candida albicans). The results showed moderate to notable antibacterial activity and up to 93% biofilm inhibition on E. coli ATCC, S. aureus, E. faecalis, and S. oralis. The anti-inflammatory effect was evaluated in vitro by inhibiting protein denaturation, with a rate of 85.5%, comparable to diclofenac. These results confirm the therapeutic potential of Psidium guajava leaves as a natural source of antioxidant, antimicrobial, anti-inflammatory, and anti-biofilm agents. |
Effets antimicrobien et biologiques de psidium guajava de la région de Tipaza [texte imprimé] / Rahma Hachelaf, Auteur ; Mouna Merrouche, Auteur . - Tipaza [Algérie] : Centre universitaire Morsli Abdellah - Tipaza-, 2024/2025 . - p.67 : couv. en noir et blanc ., ill., fig. ; 30 cm + CD. Bibliographie: p57-63.
Annexes: p64-67. Langues : Français ( fre)
| Catégories : |
Microbiologie
|
| Mots-clés : |
Psidium guajava leaves extract Soxhlet polyphenols high-performance liquid chromatography (HPLC) antioxidant antibacterial antifungal anti-biofilm anti-inflammatory flavonoids Candida albicans. |
| Index. décimale : |
579.44 |
| Résumé : |
This research focused on evaluating the phytochemical, antioxidant, antimicrobial, anti-biofilm, and anti-inflammatory properties of Psidium guajava L. (guava) leaves collected from Bou-Ismaïl (Tipaza, Algeria). Bioactive compounds were extracted using a Soxhlet apparatus with a methanol (80%)/water (20%) mixture, yielding 6.35%. HPLC analysis identified thirteen phenolic and flavonoid compounds, including gallic acid, myricetin, and apigenin. Antioxidant activity was assessed through total polyphenol content (232.5904 µg GAE/mg extract), DPPH radical scavenging (IC50 = 8 mg/L), and FRAP method (258.153 µmol Fe²⁺/g dry extract). The antimicrobial activity was tested against thirteen bacterial strains (three reference, five pathogenic, and five multidrug-resistant) and one fungal strain (Candida albicans). The results showed moderate to notable antibacterial activity and up to 93% biofilm inhibition on E. coli ATCC, S. aureus, E. faecalis, and S. oralis. The anti-inflammatory effect was evaluated in vitro by inhibiting protein denaturation, with a rate of 85.5%, comparable to diclofenac. These results confirm the therapeutic potential of Psidium guajava leaves as a natural source of antioxidant, antimicrobial, anti-inflammatory, and anti-biofilm agents. |
|  |
579.01 
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