Évaluation de l'activité anti-candida d'une formulation pharmaceutique de syzygium aromaticum dans un modèle de candidose cutanée chez des rats immunodeprimés / Nivine Allache

Public ISBD Titre : Évaluation de l'activité anti-candida d'une formulation pharmaceutique de syzygium aromaticum dans un modèle de candidose cutanée chez des rats immunodeprimés Type de document : texte imprimé Auteurs : Nivine Allache, Auteur ; aicha Debib, Auteur Editeur : Tipaza [Algérie] : Centre universitaire Morsli Abdellah - Tipaza- Année de publication : 2024/2025 Importance : p.83 Présentation : couv. en noir et blanc ., ill., fig.,tabl. Format : 30 cm Accompagnement : CD Note générale : Bibliographie: p77-79. Annexes: p 81-83. Langues : Français (fre) Catégories : Microbiologie Mots-clés : Cutaneous candidiasis  Syzygium aromaticum  Antifungal activity  Topical formulation  Animal model. Index. décimale : 579.40 Résumé : Cutaneous candidiasis, mainly caused by Candida albicans, is a common infection, especially in immunocompromised individuals. Given the limitations of conventional antifungal treatments and the emergence of drug resistance, natural alternatives are increasingly being explored. Among these, the essential oil of Syzygium aromaticum (clove), which is rich in eugenol, exhibits interesting antifungal, anti-inflammatory, and antioxidant properties. This study aims to evaluate the antifungal activity of two topical formulations (gel and cream) based on clove essential oil against Candida albicans, using an induced cutaneous candidiasis model in immunosuppressed rats. The study includes both inVitro and inVivo experiments, assessing antifungal efficacy and cutaneous tolerance. The results show notable efficacy for both formulations, with the gel demonstrating superior performance over the cream in reducing clinical signs and fungal load. These findings support the potential of the clove oil-based gel as a promising natural alternative to conventional antifungal treatments. Évaluation de l'activité anti-candida d'une formulation pharmaceutique de syzygium aromaticum dans un modèle de candidose cutanée chez des rats immunodeprimés [texte imprimé] / Nivine Allache, Auteur ; aicha Debib, Auteur . - Tipaza [Algérie] : Centre universitaire Morsli Abdellah - Tipaza-, 2024/2025 . - p.83 : couv. en noir et blanc ., ill., fig.,tabl. ; 30 cm + CD. Bibliographie: p77-79. Annexes: p 81-83. Langues : Français (fre) Catégories : Microbiologie Mots-clés : Cutaneous candidiasis  Syzygium aromaticum  Antifungal activity  Topical formulation  Animal model. Index. décimale : 579.40 Résumé : Cutaneous candidiasis, mainly caused by Candida albicans, is a common infection, especially in immunocompromised individuals. Given the limitations of conventional antifungal treatments and the emergence of drug resistance, natural alternatives are increasingly being explored. Among these, the essential oil of Syzygium aromaticum (clove), which is rich in eugenol, exhibits interesting antifungal, anti-inflammatory, and antioxidant properties. This study aims to evaluate the antifungal activity of two topical formulations (gel and cream) based on clove essential oil against Candida albicans, using an induced cutaneous candidiasis model in immunosuppressed rats. The study includes both inVitro and inVivo experiments, assessing antifungal efficacy and cutaneous tolerance. The results show notable efficacy for both formulations, with the gel demonstrating superior performance over the cream in reducing clinical signs and fungal load. These findings support the potential of the clove oil-based gel as a promising natural alternative to conventional antifungal treatments.

Exemplaires(1)

Code-barres	Cote	Support	Localisation	Section	Disponibilité
BSNV133	579.40/M	الرسائل و الأطروحـــات الجامعية	مكتبة علــــوم الطبيعة والحياة	الرسائل و الأطروحـــات الجامعية	اعارة داخلية Exclu du prêt

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